|
KMID : 0369820100400040219
|
|
Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 4 p.219 ~ p.223
|
|
|
Synthesis and Characterization of Hyaluronic Acid-α-Cyclodextrin Conjugate as the Potential Carrier of PEGylated Drugs
|
|
Sivasubramanian Maharajan
Park Jae-Hyun
|
|
|
Abstract
|
|
|
|
The hyaluronic acid (HA) conjugate bearing α-cyclodextrin (α-CD) was synthesized as the potential carrier of poly(ethylene glycol) (PEG)-drug conjugates. The HA conjugate was prepared by the reaction between the carboxylic acid of HA and the primary amine of α-CD in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole. The chemical structure of the conjugate was confirmed using 1 H NMR and FT-IR spectroscopy. The conjugate could form nano-sized particles in the presence of PEG by forming the inclusion complexes between α-CD at the backbone of HA, which was demonstrated using electrophoretic light scattering and field emission transmission electron microscopy. It is anticipated that this novel kind of nanoparticles can serve as a useful delivery system for PEGylated drugs.
|
|
|
KEYWORD
|
|
|
Hyaluronic acid, alpha-cyclodextrin, PEG, nanoparticles
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|